Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases including cancer. He...

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Veröffentlicht in:	Cell 2018-10, Vol.175 (3), p.766-779.e17
Hauptverfasser:	Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use DNA-directed RNA polymerase Drosophila Female HCT116 Cells heat shock proteins Heat-Shock Response HEK293 Cells human diseases Humans Male Mice Mice, Inbred BALB C MYC neoplasms Neoplasms, Experimental - drug therapy Positive Transcriptional Elongation Factor B - metabolism processive elongation promoter regions promoter-proximal pausing Protein Binding - drug effects Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - metabolism RNA Polymerase II - metabolism scaffolding proteins SEC Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology super elongation complex therapeutics transcription (genetics) transcription elongation Transcription Elongation, Genetic - drug effects transcriptional addiction in cancer Transcriptional Elongation Factors - metabolism
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