Racial-ethnic differences in chronic kidney disease-mineral bone disorder in youth on dialysis

Background Studies in healthy pediatric populations and adults treated with dialysis demonstrate higher parathyroid hormone (PTH) and lower 25-hydroxyvitamin D levels in African-Americans. Despite these findings, African-Americans on dialysis demonstrate greater bone strength and a decreased risk of...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2019-01, Vol.34 (1), p.107-115
Hauptverfasser:	Laster, Marciana, Soohoo, Melissa, Streja, Elani, Elashoff, Robert, Jernigan, Stephanie, Langman, Craig B., Norris, Keith C., Salusky, Isidro B., Kalantar-Zadeh, Kamyar
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Adolescent African Americans Alkaline phosphatase Biomarkers - blood Black or African American - statistics & numerical data Bone strength Bone turnover Calcium phosphates Child Child, Preschool Children Chronic Kidney Disease-Mineral and Bone Disorder - blood Chronic Kidney Disease-Mineral and Bone Disorder - diagnosis Chronic Kidney Disease-Mineral and Bone Disorder - epidemiology Chronic Kidney Disease-Mineral and Bone Disorder - etiology Cohort Studies Cultural differences Dialysis Ethnicity Female Females Health Status Disparities Hemodialysis Hispanic or Latino - statistics & numerical data Hispanic people Humans Incidence Kidney diseases Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Medicine Medicine & Public Health Minority & ethnic groups Nephrology Original Article Parathyroid Parathyroid hormone Parathyroid Hormone - blood Patients Pediatrics Race Renal Dialysis - adverse effects Risk Factors Urology Vitamin D - analogs & derivatives Vitamin D - blood What's New in Dialysis White people White People - statistics & numerical data Young Adult Young adults
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Zusammenfassung:	Background Studies in healthy pediatric populations and adults treated with dialysis demonstrate higher parathyroid hormone (PTH) and lower 25-hydroxyvitamin D levels in African-Americans. Despite these findings, African-Americans on dialysis demonstrate greater bone strength and a decreased risk of fracture compared to the Caucasian dialysis population. The presence of such differences in children and young adult dialysis patients is unknown. Methods Differences in the markers of mineral and bone metabolism (MBM) were assessed in 661 incident dialysis patients (aged 1 month to
ISSN:	0931-041X 1432-198X 1432-198X
DOI:	10.1007/s00467-018-4048-6