Peptide-based vaccination against OPN integrin binding sites does not improve cardio-metabolic disease in mice
Highlights • Active immunization with OPN-derived peptides was moderately stable in mice. • Treatment with peptide-based vaccine did not improve adipose tissue inflammation, insulin resistance and atherosclerosis in a DIO and cardio-metabolic animal model. • Further investigations should focus on ep...
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| Veröffentlicht in: | Immunology letters 2016-11, Vol.179, p.85-94 |
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| container_title | Immunology letters |
| container_volume | 179 |
| creator | Grün, Nicole G Strohmeier, Karin Moreno-Viedma, Veronica Le Bras, Marie Landlinger, Christine Zeyda, Karina Wanko, Bettina Leitner, Lukas Staffler, Günther Zeyda, Maximilian Stulnig, Thomas M |
| description | Highlights • Active immunization with OPN-derived peptides was moderately stable in mice. • Treatment with peptide-based vaccine did not improve adipose tissue inflammation, insulin resistance and atherosclerosis in a DIO and cardio-metabolic animal model. • Further investigations should focus on epitope design and novel immunization strategies. |
| doi_str_mv | 10.1016/j.imlet.2016.09.006 |
| format | Article |
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| ispartof | Immunology letters, 2016-11, Vol.179, p.85-94 |
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| subjects | Allergy and Immunology Animals Antibodies - blood Antibodies - immunology Atherosclerosis Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Binding Sites - immunology Biomarkers Cardio-metabolic disease Cross Reactions - immunology Cytokine Disease Models, Animal Heart Diseases - blood Heart Diseases - etiology Heart Diseases - metabolism Heart Diseases - therapy Immunization Inflammation - etiology Inflammation - metabolism Insulin Resistance Integrins - chemistry Integrins - metabolism Male Metabolic Diseases - blood Metabolic Diseases - etiology Metabolic Diseases - metabolism Metabolic Diseases - therapy Mice Mice, Knockout Obesity - metabolism Osteopontin Osteopontin - chemistry Osteopontin - immunology Osteopontin - metabolism Peptide Fragments - administration & dosage Peptide Fragments - immunology Protein Binding Receptors, LDL - deficiency Rodent |
| title | Peptide-based vaccination against OPN integrin binding sites does not improve cardio-metabolic disease in mice |
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