Peptide-based vaccination against OPN integrin binding sites does not improve cardio-metabolic disease in mice

Highlights • Active immunization with OPN-derived peptides was moderately stable in mice. • Treatment with peptide-based vaccine did not improve adipose tissue inflammation, insulin resistance and atherosclerosis in a DIO and cardio-metabolic animal model. • Further investigations should focus on ep...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-11, Vol.179, p.85-94
Hauptverfasser:	Grün, Nicole G, Strohmeier, Karin, Moreno-Viedma, Veronica, Le Bras, Marie, Landlinger, Christine, Zeyda, Karina, Wanko, Bettina, Leitner, Lukas, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies - blood Antibodies - immunology Atherosclerosis Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Binding Sites - immunology Biomarkers Cardio-metabolic disease Cross Reactions - immunology Cytokine Disease Models, Animal Heart Diseases - blood Heart Diseases - etiology Heart Diseases - metabolism Heart Diseases - therapy Immunization Inflammation - etiology Inflammation - metabolism Insulin Resistance Integrins - chemistry Integrins - metabolism Male Metabolic Diseases - blood Metabolic Diseases - etiology Metabolic Diseases - metabolism Metabolic Diseases - therapy Mice Mice, Knockout Obesity - metabolism Osteopontin Osteopontin - chemistry Osteopontin - immunology Osteopontin - metabolism Peptide Fragments - administration & dosage Peptide Fragments - immunology Protein Binding Receptors, LDL - deficiency Rodent
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Active immunization with OPN-derived peptides was moderately stable in mice. • Treatment with peptide-based vaccine did not improve adipose tissue inflammation, insulin resistance and atherosclerosis in a DIO and cardio-metabolic animal model. • Further investigations should focus on epitope design and novel immunization strategies.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.09.006