Systemic inflammation induces release of cell-free DNA from hematopoietic and parenchymal cells in mice and humans

During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2019-03, Vol.3 (5), p.724-728
Hauptverfasser:	van der Meer, Anne Jan, Kroeze, Anna, Hoogendijk, Arie J., Soussan, Aicha Ait, Ellen van der Schoot, C., Wuillemin, Walter A., Voermans, Carlijn, van der Poll, Tom, Zeerleder, Sacha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Cells - metabolism Cell-Free Nucleic Acids - metabolism Healthy Volunteers Humans Inflammation - pathology Kinetics Lipopolysaccharides Male Mice Neutrophils - metabolism Nucleosomes - metabolism Parenchymal Tissue - cytology Parenchymal Tissue - metabolism Sepsis - blood Severity of Illness Index Stimulus Report
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Beschreibung
Zusammenfassung:	During a systemic inflammatory response, cell-free DNA is first released by hematopoietic cells and thereafter by nonhematopoietic cells.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2018018895