Adjuvant β-Lactam Therapy Combined with Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia: Does β-Lactam Class Matter?

Adjuvant β-Lactam Therapy Combined with Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia: Does β-Lactam Class Matter?

We analyzed the impact of vancomycin (VAN) combined with adjuvant β-lactam therapy (Combo) on persistent (≥5 days) methicillin-resistant bacteremia versus VAN alone by using pooled data from two previously published observational studies (  = 156). Combo was inversely associated with persistent bact...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2019-03, Vol.63 (3)
Hauptverfasser: Dilworth, Thomas J, Casapao, Anthony M, Ibrahim, Omar M, Jacobs, David M, Bowers, Dana R, Beyda, Nicholas D, Mercier, Renee-Claude
Format: Artikel
Sprache:eng
Schlagworte:
Acute Kidney Injury - chemically induced
Anti-Bacterial Agents
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
beta-Lactams
beta-Lactams - adverse effects
beta-Lactams - therapeutic use
Clinical Therapeutics
Drug Therapy, Combination
Female
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Sensitivity Tests
Middle Aged
Observational Studies as Topic
Retrospective Studies
Staphylococcal Infections
Staphylococcal Infections - drug therapy
Treatment Outcome
Vancomycin
Vancomycin - adverse effects
Vancomycin - therapeutic use
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Zusammenfassung:We analyzed the impact of vancomycin (VAN) combined with adjuvant β-lactam therapy (Combo) on persistent (≥5 days) methicillin-resistant bacteremia versus VAN alone by using pooled data from two previously published observational studies (  = 156). Combo was inversely associated with persistent bacteremia (adjusted odds ratio, 0.460; 95% confidence interval, 0.229 to 0.923). Acute kidney injury was more common with Combo than with VAN (18.9% and 7.6%, respectively; = 0.062).
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02211-18