Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study

Abstract Context Despite sex differences in chronic kidney disease (CKD) onset and progression, it is unclear whether endogenous sex hormones are associated with kidney function in persons without CKD. Design and Methods We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2019-04, Vol.104 (4), p.1171-1180
Hauptverfasser:	Kim, Catherine, Ricardo, Ana C, Boyko, Edward J, Christophi, Costas A, Temprosa, Marinella, Watson, Karol E, Pi-Sunyer, Xavier, Kalyani, Rita R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Albumin Albuminuria - blood Albuminuria - epidemiology Albuminuria - urine Body weight Chronic kidney failure Clinical s Creatinine Creatinine - urine Cross-Sectional Studies Development and progression Diabetes Diabetes mellitus Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Diabetes Mellitus - prevention & control Diabetic Nephropathies - blood Diabetic Nephropathies - epidemiology Diabetic Nephropathies - etiology Disease Progression Epidermal growth factor receptors Estradiol - blood Female Follow-Up Studies Globulins Glomerular Filtration Rate Hormones Hormones, Sex Humans Incidence Kidney diseases Kidney Function Tests Male Measurement Middle Aged Overweight Overweight - complications Post-menopause Postmenopausal women Prevention programs Sex differences Sex Factors Sex Hormone-Binding Globulin - analysis Sex hormones Steroid hormones
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Zusammenfassung:	Abstract Context Despite sex differences in chronic kidney disease (CKD) onset and progression, it is unclear whether endogenous sex hormones are associated with kidney function in persons without CKD. Design and Methods We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and its follow-up observational study, the DPP Outcomes Study, over 11 years. Participants included overweight and glucose-intolerant men (n = 889) and pre- and postmenopausal women (n = 1281) not using exogenous sex hormones and whose urine albumin-to-creatinine ratio (ACR) was
ISSN:	0021-972X 1945-7197
DOI:	10.1210/jc.2018-01495