Activity-Regulated Cytoskeleton-Associated Protein (Arc/Arg3.1) is Transiently Expressed after Heat Shock Stress and Suppresses Heat Shock Factor 1

Heat shock proteins are induced by activation of heat shock factor 1 (HSF1) in response to heat shock and protect against heat stress. However, the molecular mechanisms underlying the downstream signal of heat shock have not been fully elucidated. We found that similarly to canonical Hsps, Arc/Arg3....

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2592-2592, Article 2592
Hauptverfasser:	Park, A Young, Park, Yeon Seung, So, Dami, Song, In-Kang, Choi, Jung-Eun, Kim, Hee-Jung, Lee, Kong-Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/109 13/2 13/89 14/19 38/61 38/77 42 631/378/1595/2167 631/378/340 631/80/386/2383 631/80/470/1981 82 82/16 82/80 96/106 Antibodies ARC protein Arsenite Cell survival Cytoskeleton Fibrosarcoma Gene expression Heat shock factors Heat shock proteins Heat tolerance HSF1 protein Hsp27 protein Hsp70 protein Humanities and Social Sciences Hydrogen peroxide Localization Molecular modelling multidisciplinary Oxidative stress Phosphorylation Proteasomes Protein synthesis Science Science (multidisciplinary) Signal transduction Sodium arsenite Ubiquitin
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Zusammenfassung:	Heat shock proteins are induced by activation of heat shock factor 1 (HSF1) in response to heat shock and protect against heat stress. However, the molecular mechanisms underlying the downstream signal of heat shock have not been fully elucidated. We found that similarly to canonical Hsps, Arc/Arg3.1 is also markedly induced by heat shock and by other cellular stress inducers, including diamide, sodium arsenite and H 2 O 2 in various cells. We noted that heat stress–induced Arc/Arg3.1 protein is short lived, with a half-life of
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-39292-1