Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. ARID1A reportedly suppresses histone deacetylase (HDAC)6 in OCCC directly. Here, we evaluated the clinical significance of HDAC6 expression and its related factors in terms of ARID1A status. Immunohistochemica...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2397-2397, Article 2397
Hauptverfasser:	Yano, Mitsutake, Katoh, Tomomi, Miyazawa, Mariko, Miyazawa, Masaki, Ogane, Naoki, Miwa, Maiko, Hasegawa, Kosei, Narahara, Hisashi, Yasuda, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/1244 692/4028/67/1517/1709 692/4028/67/1857 692/4028/67/327 692/420/2489/68 82/1 82/51 82/80 Apoptosis CD44 antigen Histone deacetylase Humanities and Social Sciences Hypoxia Medical prognosis multidisciplinary Multivariate analysis PD-1 protein PD-L1 protein Phenotypes Prognosis Science Science (multidisciplinary) Stem cells Therapeutic applications
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Zusammenfassung:	Ovarian clear cell carcinoma (OCCC) is associated with a frequent loss in ARID1A function. ARID1A reportedly suppresses histone deacetylase (HDAC)6 in OCCC directly. Here, we evaluated the clinical significance of HDAC6 expression and its related factors in terms of ARID1A status. Immunohistochemical expression of HDAC6, hypoxia inducible factors-1α (HIF-1α), programmed death-1 ligand (PD-L1), CD44 (cancer stem cell marker), and ARID1A was analysed for 106 OCCC patients. High nuclear HDAC6 expression correlated with patient death ( p = 0.038). In the multivariate analysis of overall survival, surgical status (complete or incomplete resection) (hazard ratio (HR) = 17.5; p =
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-38653-0