Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury

ABSTRACT Introduction Neurotrophin receptors, such as p75NTR, direct neuronal response to injury. Insulin‐like growth factor‐1 receptor (IGF‐1R) mediates the increase in p75NTR during aging. The aim of this study was to examine the effect of aging and insulin‐like growth factor‐1 (IGF‐1) treatment o...

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Veröffentlicht in:	Muscle & nerve 2016-10, Vol.54 (4), p.769-775
Hauptverfasser:	Luo, T. David, Alton, Timothy B., Apel, Peter J., Cai, Jiaozhong, Barnwell, Jonathan C., Sonntag, William E., Smith, Thomas L., Li, Zhongyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors aging Aging - drug effects Aging - genetics Aging - metabolism Animal behavior Animals Gene Expression IGF-1 Insulin Insulin-Like Growth Factor I - biosynthesis Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor I - therapeutic use insulin-like growth factor-1 Insulin-like growth factors Male nerve growth factor nerve regeneration neurotrophin receptor Peripheral Nerve Injuries - drug therapy Peripheral Nerve Injuries - genetics Peripheral Nerve Injuries - metabolism peripheral nerve injury Rats Rats, Inbred BN Rats, Inbred F344 Receptor, IGF Type 1 - biosynthesis Receptor, IGF Type 1 - genetics Receptors, Nerve Growth Factor - biosynthesis Receptors, Nerve Growth Factor - genetics Rodents
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Zusammenfassung:	ABSTRACT Introduction Neurotrophin receptors, such as p75NTR, direct neuronal response to injury. Insulin‐like growth factor‐1 receptor (IGF‐1R) mediates the increase in p75NTR during aging. The aim of this study was to examine the effect of aging and insulin‐like growth factor‐1 (IGF‐1) treatment on recovery after peripheral nerve injury. Methods Young and aged rats underwent tibial nerve transection with either local saline or IGF‐1 treatment. Neurotrophin receptor mRNA and protein expression were quantified. Results Aged rats expressed elevated baseline IGF‐1R (34% higher, P = 0.01) and p75NTR (68% higher, P
ISSN:	0148-639X 1097-4598
DOI:	10.1002/mus.25106