CAPAM: The mRNA Cap Adenosine N6-Methyltransferase
The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the functio...
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| Veröffentlicht in: | Trends in biochemical sciences (Amsterdam. Regular ed.) 2019-03, Vol.44 (3), p.183-185 |
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| container_title | Trends in biochemical sciences (Amsterdam. Regular ed.) |
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| creator | Cowling, Victoria H. |
| description | The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation. |
| doi_str_mv | 10.1016/j.tibs.2019.01.002 |
| format | Article |
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A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.</description><identifier>ISSN: 0968-0004</identifier><identifier>EISSN: 1362-4326</identifier><identifier>DOI: 10.1016/j.tibs.2019.01.002</identifier><identifier>PMID: 30679132</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adenosine ; Adenosine - metabolism ; Animals ; CAPAM ; gene expression ; Humans ; m6Am ; messenger RNA ; Methylation ; Methyltransferases - metabolism ; mRNA cap ; mRNA cap methyltransferase ; Pcif1 ; RNA Caps - metabolism ; RNA, Messenger - metabolism ; transcription (genetics) ; transferases ; translation (genetics)</subject><ispartof>Trends in biochemical sciences (Amsterdam. Regular ed.), 2019-03, Vol.44 (3), p.183-185</ispartof><rights>2019 The Author</rights><rights>Copyright © 2019 The Author. 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| fulltext | fulltext |
| identifier | ISSN: 0968-0004 |
| ispartof | Trends in biochemical sciences (Amsterdam. Regular ed.), 2019-03, Vol.44 (3), p.183-185 |
| issn | 0968-0004 1362-4326 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6378647 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adenosine Adenosine - metabolism Animals CAPAM gene expression Humans m6Am messenger RNA Methylation Methyltransferases - metabolism mRNA cap mRNA cap methyltransferase Pcif1 RNA Caps - metabolism RNA, Messenger - metabolism transcription (genetics) transferases translation (genetics) |
| title | CAPAM: The mRNA Cap Adenosine N6-Methyltransferase |
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