CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

CAPAM: The mRNA Cap Adenosine N6-Methyltransferase

The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the functio...

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Veröffentlicht in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2019-03, Vol.44 (3), p.183-185
1. Verfasser: Cowling, Victoria H.
Format: Artikel
Sprache:eng
Schlagworte:
adenosine
Adenosine - metabolism
Animals
CAPAM
gene expression
Humans
m6Am
messenger RNA
Methylation
Methyltransferases - metabolism
mRNA cap
mRNA cap methyltransferase
Pcif1
RNA Caps - metabolism
RNA, Messenger - metabolism
transcription (genetics)
transferases
translation (genetics)
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Beschreibung
Zusammenfassung:The mRNA cap is a structure that protects mRNA from degradation and recruits processing and translation factors. A new mRNA capping enzyme has been identified, PCIF1/CAPAM, which methylates adenosine when it is the first transcribed nucleotide. This discovery is crucial for understanding the function of cap adenosine methylation.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2019.01.002