Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals
Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal f...
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| Veröffentlicht in: | Scientific reports 2019-02, Vol.9 (1), p.1959-1959, Article 1959 |
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| creator | Schön, M. Kovaničová, Z. Košutzká, Z. Nemec, M. Tomková, M. Jacková, L. Máderová, D. Slobodová, L. Valkovič, P. Ukropec, J. Ukropcová, B. |
| description | Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75–80% HRmax; maximal heart rate), additional serum was taken at finish-line. Body composition, physical fitness, metabolic rate, cognitive functions, food preference, glucose, insulin and albumin were measured. The spectrum of 174 cytokines was assessed by protein arrays, adiponectin was also determined by ELISA and immunoblotting. CSF adiponectin decreased post-exercise by 21.3% (arrays) and 25.8% (ELISA) (p |
| doi_str_mv | 10.1038/s41598-018-38201-2 |
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We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75–80% HRmax; maximal heart rate), additional serum was taken at finish-line. Body composition, physical fitness, metabolic rate, cognitive functions, food preference, glucose, insulin and albumin were measured. The spectrum of 174 cytokines was assessed by protein arrays, adiponectin was also determined by ELISA and immunoblotting. CSF adiponectin decreased post-exercise by 21.3% (arrays) and 25.8% (ELISA) (p < 0.009). Immunoblotting revealed reduction in a low-molecular-weight-adiponectin (p < 0.005). CSF adiponectin positively correlated with CSF/serum albumin ratio (p < 0.022), an indicator of blood-brain-barrier permeability. CSF and serum adiponectin were positively associated with memory and running-induced changes in insulinemia and CSF insulin. Additionally, running modulated CSF levels of 16 other cytokines. Acute running reduced CSF adiponectin and modulated insulin and albumin in CSF and serum. Associations of adiponectin with memory and metabolism indicate the potential role of this bioactive molecule in mediating exercise-induced adaptive response in human brain.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-38201-2</identifier><identifier>PMID: 30760755</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/21 ; 631/443/319/367 ; 631/443/376 ; 692/308/2778 ; 82/1 ; Adiponectin ; Albumin ; Body composition ; Brain ; Cerebrospinal fluid ; Cognitive ability ; Cytokines ; Enzyme-linked immunosorbent assay ; Exercise ; Food preferences ; Heart rate ; Humanities and Social Sciences ; Immunoblotting ; Insulin ; Memory ; Metabolic rate ; Metabolism ; multidisciplinary ; Permeability ; Physical fitness ; Physical training ; Protein arrays ; Running ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2019-02, Vol.9 (1), p.1959-1959, Article 1959</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ae47314d67fecbdca4559e4d511dfa680673a0236cd1ea22022a6fe0a20f5f993</citedby><cites>FETCH-LOGICAL-c474t-ae47314d67fecbdca4559e4d511dfa680673a0236cd1ea22022a6fe0a20f5f993</cites><orcidid>0000-0002-1911-2112</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374465/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374465/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,41103,42172,51559,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30760755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schön, M.</creatorcontrib><creatorcontrib>Kovaničová, Z.</creatorcontrib><creatorcontrib>Košutzká, Z.</creatorcontrib><creatorcontrib>Nemec, M.</creatorcontrib><creatorcontrib>Tomková, M.</creatorcontrib><creatorcontrib>Jacková, L.</creatorcontrib><creatorcontrib>Máderová, D.</creatorcontrib><creatorcontrib>Slobodová, L.</creatorcontrib><creatorcontrib>Valkovič, P.</creatorcontrib><creatorcontrib>Ukropec, J.</creatorcontrib><creatorcontrib>Ukropcová, B.</creatorcontrib><title>Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75–80% HRmax; maximal heart rate), additional serum was taken at finish-line. Body composition, physical fitness, metabolic rate, cognitive functions, food preference, glucose, insulin and albumin were measured. The spectrum of 174 cytokines was assessed by protein arrays, adiponectin was also determined by ELISA and immunoblotting. CSF adiponectin decreased post-exercise by 21.3% (arrays) and 25.8% (ELISA) (p < 0.009). Immunoblotting revealed reduction in a low-molecular-weight-adiponectin (p < 0.005). CSF adiponectin positively correlated with CSF/serum albumin ratio (p < 0.022), an indicator of blood-brain-barrier permeability. CSF and serum adiponectin were positively associated with memory and running-induced changes in insulinemia and CSF insulin. Additionally, running modulated CSF levels of 16 other cytokines. Acute running reduced CSF adiponectin and modulated insulin and albumin in CSF and serum. Associations of adiponectin with memory and metabolism indicate the potential role of this bioactive molecule in mediating exercise-induced adaptive response in human brain.</description><subject>13/21</subject><subject>631/443/319/367</subject><subject>631/443/376</subject><subject>692/308/2778</subject><subject>82/1</subject><subject>Adiponectin</subject><subject>Albumin</subject><subject>Body composition</subject><subject>Brain</subject><subject>Cerebrospinal fluid</subject><subject>Cognitive ability</subject><subject>Cytokines</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Exercise</subject><subject>Food preferences</subject><subject>Heart rate</subject><subject>Humanities and Social Sciences</subject><subject>Immunoblotting</subject><subject>Insulin</subject><subject>Memory</subject><subject>Metabolic rate</subject><subject>Metabolism</subject><subject>multidisciplinary</subject><subject>Permeability</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Protein arrays</subject><subject>Running</subject><subject>Science</subject><subject>Science 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Rep</addtitle><date>2019-02-13</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>1959</spage><epage>1959</epage><pages>1959-1959</pages><artnum>1959</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and 1-h after the 90-min run (75–80% HRmax; maximal heart rate), additional serum was taken at finish-line. Body composition, physical fitness, metabolic rate, cognitive functions, food preference, glucose, insulin and albumin were measured. The spectrum of 174 cytokines was assessed by protein arrays, adiponectin was also determined by ELISA and immunoblotting. CSF adiponectin decreased post-exercise by 21.3% (arrays) and 25.8% (ELISA) (p < 0.009). Immunoblotting revealed reduction in a low-molecular-weight-adiponectin (p < 0.005). CSF adiponectin positively correlated with CSF/serum albumin ratio (p < 0.022), an indicator of blood-brain-barrier permeability. CSF and serum adiponectin were positively associated with memory and running-induced changes in insulinemia and CSF insulin. Additionally, running modulated CSF levels of 16 other cytokines. Acute running reduced CSF adiponectin and modulated insulin and albumin in CSF and serum. Associations of adiponectin with memory and metabolism indicate the potential role of this bioactive molecule in mediating exercise-induced adaptive response in human brain.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30760755</pmid><doi>10.1038/s41598-018-38201-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1911-2112</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13/21 631/443/319/367 631/443/376 692/308/2778 82/1 Adiponectin Albumin Body composition Brain Cerebrospinal fluid Cognitive ability Cytokines Enzyme-linked immunosorbent assay Exercise Food preferences Heart rate Humanities and Social Sciences Immunoblotting Insulin Memory Metabolic rate Metabolism multidisciplinary Permeability Physical fitness Physical training Protein arrays Running Science Science (multidisciplinary) |
| title | Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals |
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