Very low prevalence of anti-HAV in Japan: high potential for future outbreak

Since the early 21 st century, almost all developed countries have had a very low hepatitis A virus antibody (anti-HAV) sero-prevalence profile, as sanitation conditions and health care facilities have been optimized to a universal standard. There has not been a report on anti-HAV prevalence among a...

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Veröffentlicht in:Scientific reports 2019-02, Vol.9 (1), p.1493-1493, Article 1493
Hauptverfasser: Yamamoto, Chikako, Ko, Ko, Nagashima, Shintaro, Harakawa, Takayuki, Fujii, Toshiko, Ohisa, Masayuki, Katayama, Keiko, Takahashi, Kazuaki, Okamoto, Hiroaki, Tanaka, Junko
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Sprache:eng
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Zusammenfassung:Since the early 21 st century, almost all developed countries have had a very low hepatitis A virus antibody (anti-HAV) sero-prevalence profile, as sanitation conditions and health care facilities have been optimized to a universal standard. There has not been a report on anti-HAV prevalence among a large scale population in Japan since 2003. Therefore, this study aimed to investigate the current HAV status among the general population in Hiroshima. From each age and sex specific group, a total of 1,200 samples were randomly selected from 7,682 stocked serum samples from residents’ and employees’ annual health check-ups during 2013–2015. Total anti-HAV was detected using Chemiluminescent Enzyme Immunoassay. The overall anti-HAV sero-prevalence was 16.8%. In both males and females, anti-HAV prevalence among individuals between 20–59 years of age was as low as 0.0–2.0%, whilst that among 70 s was as high as 70.0–71.0%. A large number of residents aged under 60 are now susceptible to HAV infection. The cohort reduction trend of anti-HAV in Japan exposes the high possibility of mass outbreak in the future. HAV vaccine especially to younger generation and high risk population may prevent outbreak in Japan.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-37349-1