Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions
[Display omitted] Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The r...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2019-02, Vol.29 (4), p.619-622 |
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| container_end_page | 622 |
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| container_issue | 4 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 29 |
| creator | Guillon, Christophe D. Jan, Yi-Hua Foster, Natalie Ressner, Joel Heck, Diane E. Laskin, Jeffrey D. Heindel, Ned D. |
| description | [Display omitted]
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture. |
| doi_str_mv | 10.1016/j.bmcl.2018.12.048 |
| format | Article |
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Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2018.12.048</identifier><identifier>PMID: 30638875</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>8-Methoxypsoralen ; 8-MOP ; Cell Survival - drug effects ; Cells, Cultured ; Dark-reaction toxicity ; Darkness ; Humans ; Keratinocytes ; Keratinocytes - drug effects ; Keratinocytes - radiation effects ; Light ; Methoxsalen - chemistry ; Methoxsalen - pharmacology ; PAM212 ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Phototoxicity ; Skin Diseases - pathology</subject><ispartof>Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.619-622</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-f8a10bad9fb5d31142365ca21c879b18a31d26a7e8f2279090b8695bff441f7f3</citedby><cites>FETCH-LOGICAL-c455t-f8a10bad9fb5d31142365ca21c879b18a31d26a7e8f2279090b8695bff441f7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2018.12.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30638875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guillon, Christophe D.</creatorcontrib><creatorcontrib>Jan, Yi-Hua</creatorcontrib><creatorcontrib>Foster, Natalie</creatorcontrib><creatorcontrib>Ressner, Joel</creatorcontrib><creatorcontrib>Heck, Diane E.</creatorcontrib><creatorcontrib>Laskin, Jeffrey D.</creatorcontrib><creatorcontrib>Heindel, Ned D.</creatorcontrib><title>Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.</description><subject>8-Methoxypsoralen</subject><subject>8-MOP</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Dark-reaction toxicity</subject><subject>Darkness</subject><subject>Humans</subject><subject>Keratinocytes</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - radiation effects</subject><subject>Light</subject><subject>Methoxsalen - chemistry</subject><subject>Methoxsalen - pharmacology</subject><subject>PAM212</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Phototoxicity</subject><subject>Skin Diseases - pathology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMozjj6Ai4kL9CapGmagggi3mDAhQruQpqLzdgmkkaxb2-H0UE3rs7iP_93OB8AxxjlGGF2usqbXnU5QZjnmOSI8h0wx5TRrKCo3AVzVDOU8Zo-z8DBMKwQwhRRug9mBWIF51U5B88Po0-tSU7JrhthH7SzzmjYm9SGz0F2xkMbIjS-lV5NgRpTSOHTKZdG6Dzs3EuboPQaahlfYTRSJRf8cAj2rOwGc_Q9F-Dp-urx8jZb3t_cXV4sM0XLMmWWS4waqWvblLrAmJKClUoSrHhVN5jLAmvCZGW4JaSqUY0azuqysZZSbCtbLMD5hvv23vRGK-NTlJ14i66XcRRBOvE38a4VL-FDsILRskITgGwAKoZhiMZuuxiJtWexEmvPYu1ZYCImz1Pp5PfVbeVH7LRwtlkw0-8fzkQxKGfWBl00Kgkd3H_8L7vekh0</recordid><startdate>20190215</startdate><enddate>20190215</enddate><creator>Guillon, Christophe D.</creator><creator>Jan, Yi-Hua</creator><creator>Foster, Natalie</creator><creator>Ressner, Joel</creator><creator>Heck, Diane E.</creator><creator>Laskin, Jeffrey D.</creator><creator>Heindel, Ned D.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190215</creationdate><title>Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions</title><author>Guillon, Christophe D. ; Jan, Yi-Hua ; Foster, Natalie ; Ressner, Joel ; Heck, Diane E. ; Laskin, Jeffrey D. ; Heindel, Ned D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-f8a10bad9fb5d31142365ca21c879b18a31d26a7e8f2279090b8695bff441f7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>8-Methoxypsoralen</topic><topic>8-MOP</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Dark-reaction toxicity</topic><topic>Darkness</topic><topic>Humans</topic><topic>Keratinocytes</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - radiation effects</topic><topic>Light</topic><topic>Methoxsalen - chemistry</topic><topic>Methoxsalen - pharmacology</topic><topic>PAM212</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Phototoxicity</topic><topic>Skin Diseases - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillon, Christophe D.</creatorcontrib><creatorcontrib>Jan, Yi-Hua</creatorcontrib><creatorcontrib>Foster, Natalie</creatorcontrib><creatorcontrib>Ressner, Joel</creatorcontrib><creatorcontrib>Heck, Diane E.</creatorcontrib><creatorcontrib>Laskin, Jeffrey D.</creatorcontrib><creatorcontrib>Heindel, Ned D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillon, Christophe D.</au><au>Jan, Yi-Hua</au><au>Foster, Natalie</au><au>Ressner, Joel</au><au>Heck, Diane E.</au><au>Laskin, Jeffrey D.</au><au>Heindel, Ned D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2019-02-15</date><risdate>2019</risdate><volume>29</volume><issue>4</issue><spage>619</spage><epage>622</epage><pages>619-622</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30638875</pmid><doi>10.1016/j.bmcl.2018.12.048</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.619-622 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6364570 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 8-Methoxypsoralen 8-MOP Cell Survival - drug effects Cells, Cultured Dark-reaction toxicity Darkness Humans Keratinocytes Keratinocytes - drug effects Keratinocytes - radiation effects Light Methoxsalen - chemistry Methoxsalen - pharmacology PAM212 Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Phototoxicity Skin Diseases - pathology |
| title | Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions |
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