Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions
[Display omitted] Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The r...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2019-02, Vol.29 (4), p.619-622 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | [Display omitted]
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2018.12.048 |