Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

[Display omitted] Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The r...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2019-02, Vol.29 (4), p.619-622
Hauptverfasser: Guillon, Christophe D., Jan, Yi-Hua, Foster, Natalie, Ressner, Joel, Heck, Diane E., Laskin, Jeffrey D., Heindel, Ned D.
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Sprache:eng
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Zusammenfassung:[Display omitted] Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2018.12.048