Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin

Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin

Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast , is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defective mitochondrial dynamics and function...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of cell biology 2019-02, Vol.218 (2), p.391-392
Hauptverfasser: Leandro, João, Houten, Sander M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Commentaries
Homeostasis
Lysine
Lysine - analogs & derivatives
Mice
Mitochondria
Saccharomyces cerevisiae
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast , is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defective mitochondrial dynamics and function in worm and mouse models.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201901033