Ablation Lesion Characterization in Scarred Substrate Assessed Using Cardiac Magnetic Resonance

This study examined radiofrequency catheter ablation (RFCA) lesions within and around scar by cardiac magnetic resonance (CMR) imaging and histology. Substrate modification by RFCA is the cornerstone therapy for ventricular arrhythmias. RFCA in scarred myocardium, however, is not well understood. We...

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Veröffentlicht in:	JACC. Clinical electrophysiology 2019-01, Vol.5 (1), p.91-100
Hauptverfasser:	Tao, Susumu, Guttman, Michael A., Fink, Sarah, Elahi, Hassan, Patil, Kaustubha D., Ashikaga, Hiroshi, Kolandaivelu, Aravindan D., Berger, Ronald D., Halushka, Marc K., Schmidt, Ehud J., Herzka, Daniel A., Halperin, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - physiopathology Arrhythmias, Cardiac - surgery Cardiac Imaging Techniques - methods cardiac magnetic resonance Catheter Ablation Cicatrix - diagnostic imaging Cicatrix - physiopathology Electrophysiologic Techniques, Cardiac - methods Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Magnetic Resonance Imaging - methods myocardial infarction Myocardial Infarction - physiopathology Myocardial Infarction - surgery non-contrast-enhanced T1-weighted imaging radiofrequency catheter ablation Swine ventricular arrhythmia
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Zusammenfassung:	This study examined radiofrequency catheter ablation (RFCA) lesions within and around scar by cardiac magnetic resonance (CMR) imaging and histology. Substrate modification by RFCA is the cornerstone therapy for ventricular arrhythmias. RFCA in scarred myocardium, however, is not well understood. We performed electroanatomic mapping and RFCA in the left ventricles of 8 swine with myocardial infarction. Non-contrast-enhanced T1-weighted (T1w) and contrast-enhanced CMR after RFCA were compared with gross pathology and histology. Of 59 lesions, 17 were in normal myocardium (voltage >1.5 mV), 21 in border zone (0.5 to 1.5 mV), and 21 in scar (
ISSN:	2405-500X 2405-5018
DOI:	10.1016/j.jacep.2018.11.001