CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus
C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease. The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls. Present study was done by allele specific...
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| Veröffentlicht in: | Open access Macedonian journal of medical sciences 2019-01, Vol.7 (1), p.33-37 |
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| creator | Jebur, Hakim Bahlok Masroor, Mirza Ahmad, Hafiz Khan, Naushad Ahmad Akther, Juheb Bharali, Dipu Singh, Vijay Kumar Verma, Amit Khan, Shahbaz Khan, Vasiuddin Hasan, Rameez Bhatt, Deepti Goyal, Yamini Dev, Kapil |
| description | C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.
The present study evaluates the association of CRP +1059 G/C polymorphism of the
gene in 100 T2D cases and 100 healthy controls.
Present study was done by allele specific PCR method to study the
gene polymorphism in study subjects.
Study found that
(+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher
C allele frequency (0.16) was observed compared to controls (0.04).
+1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.
Study concluded that
gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes. |
| doi_str_mv | 10.3889/oamjms.2019.014 |
| format | Article |
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The present study evaluates the association of CRP +1059 G/C polymorphism of the
gene in 100 T2D cases and 100 healthy controls.
Present study was done by allele specific PCR method to study the
gene polymorphism in study subjects.
Study found that
(+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher
C allele frequency (0.16) was observed compared to controls (0.04).
+1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.
Study concluded that
gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.</description><identifier>ISSN: 1857-9655</identifier><identifier>EISSN: 1857-9655</identifier><identifier>DOI: 10.3889/oamjms.2019.014</identifier><identifier>PMID: 30740156</identifier><language>eng</language><publisher>Macedonia: Republic of Macedonia</publisher><subject>Basic Science</subject><ispartof>Open access Macedonian journal of medical sciences, 2019-01, Vol.7 (1), p.33-37</ispartof><rights>Copyright: © 2019 Hakim Bahlok Jebur, Mirza Masroor, Hafiz Ahmad, Naushad Ahmad Khan, Juheb Akther, Dipu Bharali, Vijay Kumar Singh, Amit Verma, Shahbaz Khan, Vasiuddin Khan, Rameez Hasan, Deepti Bhatt, Yamini Goyal, Kapil Dev. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3084-dcad91d1fa924bce01ae36353e033e17a45b702ab0a65d6d1e297f157d1c73cb3</citedby><cites>FETCH-LOGICAL-c3084-dcad91d1fa924bce01ae36353e033e17a45b702ab0a65d6d1e297f157d1c73cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352458/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352458/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30740156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jebur, Hakim Bahlok</creatorcontrib><creatorcontrib>Masroor, Mirza</creatorcontrib><creatorcontrib>Ahmad, Hafiz</creatorcontrib><creatorcontrib>Khan, Naushad Ahmad</creatorcontrib><creatorcontrib>Akther, Juheb</creatorcontrib><creatorcontrib>Bharali, Dipu</creatorcontrib><creatorcontrib>Singh, Vijay Kumar</creatorcontrib><creatorcontrib>Verma, Amit</creatorcontrib><creatorcontrib>Khan, Shahbaz</creatorcontrib><creatorcontrib>Khan, Vasiuddin</creatorcontrib><creatorcontrib>Hasan, Rameez</creatorcontrib><creatorcontrib>Bhatt, Deepti</creatorcontrib><creatorcontrib>Goyal, Yamini</creatorcontrib><creatorcontrib>Dev, Kapil</creatorcontrib><title>CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus</title><title>Open access Macedonian journal of medical sciences</title><addtitle>Open Access Maced J Med Sci</addtitle><description>C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.
The present study evaluates the association of CRP +1059 G/C polymorphism of the
gene in 100 T2D cases and 100 healthy controls.
Present study was done by allele specific PCR method to study the
gene polymorphism in study subjects.
Study found that
(+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher
C allele frequency (0.16) was observed compared to controls (0.04).
+1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.
Study concluded that
gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.</description><subject>Basic Science</subject><issn>1857-9655</issn><issn>1857-9655</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVUU1PwkAQ3RiNEOTszezRC7Af3X5cTAgqmqASgvG42W6ndrHt1m5rwr-3BCR4mpnMm_dm5iF0TcmYh2E0sarYFG7MCI3GhHpnqE9DEYwiX4jzk7yHhs5tCCFURD5l7BL1OAm8rvT76HW2WuI5lICXNt8Wtq4y4wqsygSvMzA1Xhn3hafOWW1UY2yJP0yT4fW2AszwvVExNODwC-S5aVp3hS5SlTsYHuIAvT8-rGdPo8Xb_Hk2XYw0J6E3SrRKIprQVEXMizUQqoD7XHAgnAMNlCfigDAVE-WLxE8osChIqQgSqgOuYz5Ad3veqo0LSDSUTa1yWdWmUPVWWmXk_05pMvlpf2QnwjwRdgS3B4LafrfgGlkYp7srVAm2dZIxFpHue2wHneyhurbO1ZAeZSiROyPk3gi5M0J2RnQTN6fbHfF_b-e_3uyFpg</recordid><startdate>20190115</startdate><enddate>20190115</enddate><creator>Jebur, Hakim Bahlok</creator><creator>Masroor, Mirza</creator><creator>Ahmad, Hafiz</creator><creator>Khan, Naushad Ahmad</creator><creator>Akther, Juheb</creator><creator>Bharali, Dipu</creator><creator>Singh, Vijay Kumar</creator><creator>Verma, Amit</creator><creator>Khan, Shahbaz</creator><creator>Khan, Vasiuddin</creator><creator>Hasan, Rameez</creator><creator>Bhatt, Deepti</creator><creator>Goyal, Yamini</creator><creator>Dev, Kapil</creator><general>Republic of Macedonia</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190115</creationdate><title>CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus</title><author>Jebur, Hakim Bahlok ; Masroor, Mirza ; Ahmad, Hafiz ; Khan, Naushad Ahmad ; Akther, Juheb ; Bharali, Dipu ; Singh, Vijay Kumar ; Verma, Amit ; Khan, Shahbaz ; Khan, Vasiuddin ; Hasan, Rameez ; Bhatt, Deepti ; Goyal, Yamini ; Dev, Kapil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3084-dcad91d1fa924bce01ae36353e033e17a45b702ab0a65d6d1e297f157d1c73cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Basic Science</topic><toplevel>online_resources</toplevel><creatorcontrib>Jebur, Hakim Bahlok</creatorcontrib><creatorcontrib>Masroor, Mirza</creatorcontrib><creatorcontrib>Ahmad, Hafiz</creatorcontrib><creatorcontrib>Khan, Naushad Ahmad</creatorcontrib><creatorcontrib>Akther, Juheb</creatorcontrib><creatorcontrib>Bharali, Dipu</creatorcontrib><creatorcontrib>Singh, Vijay Kumar</creatorcontrib><creatorcontrib>Verma, Amit</creatorcontrib><creatorcontrib>Khan, Shahbaz</creatorcontrib><creatorcontrib>Khan, Vasiuddin</creatorcontrib><creatorcontrib>Hasan, Rameez</creatorcontrib><creatorcontrib>Bhatt, Deepti</creatorcontrib><creatorcontrib>Goyal, Yamini</creatorcontrib><creatorcontrib>Dev, Kapil</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open access Macedonian journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jebur, Hakim Bahlok</au><au>Masroor, Mirza</au><au>Ahmad, Hafiz</au><au>Khan, Naushad Ahmad</au><au>Akther, Juheb</au><au>Bharali, Dipu</au><au>Singh, Vijay Kumar</au><au>Verma, Amit</au><au>Khan, Shahbaz</au><au>Khan, Vasiuddin</au><au>Hasan, Rameez</au><au>Bhatt, Deepti</au><au>Goyal, Yamini</au><au>Dev, Kapil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus</atitle><jtitle>Open access Macedonian journal of medical sciences</jtitle><addtitle>Open Access Maced J Med Sci</addtitle><date>2019-01-15</date><risdate>2019</risdate><volume>7</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>1857-9655</issn><eissn>1857-9655</eissn><abstract>C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.
The present study evaluates the association of CRP +1059 G/C polymorphism of the
gene in 100 T2D cases and 100 healthy controls.
Present study was done by allele specific PCR method to study the
gene polymorphism in study subjects.
Study found that
(+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher
C allele frequency (0.16) was observed compared to controls (0.04).
+1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.
Study concluded that
gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.</abstract><cop>Macedonia</cop><pub>Republic of Macedonia</pub><pmid>30740156</pmid><doi>10.3889/oamjms.2019.014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| title | CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus |
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