CRP Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus

C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease. The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls. Present study was done by allele specific PCR method to study the gene polymorphism in study subjects. Study found that (+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher C allele frequency (0.16) was observed compared to controls (0.04). +1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters. Study concluded that gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.