Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice
Increasing evidence indicates that pattern recognition receptors (PRRs) are involved in neuropathic pain after peripheral nerve injury (PNI). While a significant number of studies support an association between neuropathic pain and the innate immune response mediated through Toll-like receptors, a f...
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Veröffentlicht in: | Scientific reports 2019-01, Vol.9 (1), p.872-872, Article 872 |
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Sprache: | eng |
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Zusammenfassung: | Increasing evidence indicates that pattern recognition receptors (PRRs) are involved in neuropathic pain after peripheral nerve injury (PNI). While a significant number of studies support an association between neuropathic pain and the innate immune response mediated through Toll-like receptors, a family of PRRs, the roles of other types of PRRs are largely unknown. In this study, we have focused on the macrophage-inducible C-type lectin (Mincle), a PRR allocated to the C-type lectin receptor family. Here, we show that Mincle is involved in neuropathic pain after PNI.
Mincle
-deficient mice showed impaired PNI-induced mechanical allodynia. After PNI, expression of
Mincle
mRNA was rapidly increased in the injured spinal nerve. Most
Mincle
-expressing cells were identified as infiltrating leucocytes, although the migration of leucocytes was also observed in
Mincle
-deficient mice. Furthermore,
Mincle
-deficiency affected the induction of genes, which are reported to contribute to neuropathic pain after PNI in the dorsal root ganglia and spinal dorsal horn. These results suggest that Mincle is involved in triggering sequential processes that lead to the pathogenesis of neuropathic pain. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-018-37318-8 |