Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Corin Is Downregulated in Renal Ischemia/Reperfusion Injury and Is Associated with Delayed Graft Function after Kidney Transplantation

Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of...

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Veröffentlicht in:Disease markers 2019-01, Vol.2019 (2019), p.1-8
Hauptverfasser: Qiu, Wei, Zhang, Jian, Sun, Wen, Zhang, Lei, Lin, Jun, Su, Ming, Hu, Xinyi, Tian, Ye
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Biomarkers
Cardiology
Enzyme-linked immunosorbent assay
Enzymes
Genes
Heart failure
Hospitals
Hypertension
Injury prevention
Ischemia
Kidney transplantation
Kidneys
Mice
Peptides
Physiology
Proteins
Renal function
Reperfusion
Risk analysis
Risk factors
Studies
Transplantation
Transplants & implants
Tumor necrosis factor-TNF
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Zusammenfassung:Renal ischemia/reperfusion (IR) injury is one of the most important risk factors for the occurrence of delayed graft function (DGF) after kidney transplantation; however, its mechanism remains not fully understood. In the present study, we screened differentially expressed genes in a murine model of renal IR injury by using high-throughput assays. We identified Corin as one of the most significantly downregulated genes among 2218 differentially expressed genes (≥2-fold, P
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/9429323