The Difference δ-Cells Make in Glucose Control

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop bet...

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Veröffentlicht in:	Physiology (Bethesda, Md.) Md.), 2018-11, Vol.33 (6), p.403-411
Hauptverfasser:	Huising, Mark O, van der Meulen, Talitha, Huang, Jessica L, Pourhosseinzadeh, Mohammad S, Noguchi, Glyn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Glucose - metabolism Humans Insulin - metabolism Insulin Secretion - physiology Insulin-Secreting Cells - metabolism Islets of Langerhans - metabolism Review Somatostatin-Secreting Cells - metabolism
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Beschreibung
Zusammenfassung:	The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.
ISSN:	1548-9213 1548-9221 1548-9221
DOI:	10.1152/physiol.00029.2018