Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mo...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2017-11, Vol.153 (5), p.1212-1226
Hauptverfasser: Gukovskaya, Anna S., Gukovsky, Ilya, Algül, Hana, Habtezion, Aida
Format: Artikel
Sprache:eng
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Zusammenfassung:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease severity depends on whether the inflammatory response resolves or amplifies, leading to multi-organ failure. Dysregulated autophagy might promote the inflammatory response in the pancreas. We discuss the roles of autophagy and inflammation in pancreatitis, mechanisms of deregulation, and connections among disordered pathways. We identify gaps in our knowledge and delineate perspective directions for research. Elucidation of pathogenic mechanisms could lead to new targets for treating or reducing the severity of pancreatitis.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2017.08.071