Nutrient Competition: A New Axis of Tumor Immunosuppression

It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunit...

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Veröffentlicht in:	Cell 2015-09, Vol.162 (6), p.1206-1208
Hauptverfasser:	Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Restifo, Nicholas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism cell growth glucose Glycolysis immunosuppression Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Melanoma - immunology Melanoma - therapy metabolism Monitoring, Immunologic neoplasm cells neoplasms Neoplasms - metabolism Phosphoenolpyruvate - metabolism T-lymphocytes Tumor Microenvironment
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Zusammenfassung:	It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity. It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2015.08.064