The mTOR Independent Function of Tsc1 and FNIPs

New roles for Tsc1 and FNIP1/2 as regulators of the molecular chaperone Hsp90 were recently identified, demonstrating a broader cellular impact outside of AMPK-mTOR signaling. In studying the function of these proteins we must take a holistic view of the cell, instead of maintaining our focus on a s...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2018-12, Vol.43 (12), p.935-937
Hauptverfasser:	Sager, Rebecca A., Woodford, Mark R., Mollapour, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Birt-Hogg-Dubé syndrome Carrier Proteins - metabolism cell physiology co-chaperone heat-shock protein 90 Hsp90 Humans mTOR protein-protein interactions TOR Serine-Threonine Kinases - metabolism Tuberous Sclerosis - metabolism tuberous sclerosis complex Tuberous Sclerosis Complex 1 Protein - metabolism
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Beschreibung
Zusammenfassung:	New roles for Tsc1 and FNIP1/2 as regulators of the molecular chaperone Hsp90 were recently identified, demonstrating a broader cellular impact outside of AMPK-mTOR signaling. In studying the function of these proteins we must take a holistic view of the cell, instead of maintaining our focus on a single pathway.
ISSN:	0968-0004 1362-4326
DOI:	10.1016/j.tibs.2018.09.018