Going the distance: Neocentromeres make long-range contacts with heterochromatin

Going the distance: Neocentromeres make long-range contacts with heterochromatin

Neocentromeres are ectopic centromeres that form at noncanonical, usually nonrepetitive, genomic locations. Nishimura et al. (2019. https://doi.org/10.1083/jcb.201805003) explore the three-dimensional architecture of vertebrate neocentromeres, leading to a model for centromere function and maintenan...

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Veröffentlicht in:The Journal of cell biology 2019-01, Vol.218 (1), p.5-7
Hauptverfasser: McNulty, Shannon M, Sullivan, Beth A
Format: Artikel
Sprache:eng
Schlagworte:
Bioengineering
Cell Nucleus
Centromere
Centromere Protein A
Centromeres
Clustering
Commentaries
Enzymes
Genomics
Heterochromatin
Nuclear chemistry
Three dimensional models
Vertebrates
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Zusammenfassung:Neocentromeres are ectopic centromeres that form at noncanonical, usually nonrepetitive, genomic locations. Nishimura et al. (2019. https://doi.org/10.1083/jcb.201805003) explore the three-dimensional architecture of vertebrate neocentromeres, leading to a model for centromere function and maintenance via nuclear clustering with heterochromatin.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.201811172