Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients
Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from...
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| Veröffentlicht in: | Oncology letters 2019-01, Vol.17 (1), p.871-876 |
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| creator | Xu, Wei Qi, Xiaogai Wang, Xia Sun, Jize |
| description | Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer-adjacent tissues (P |
| doi_str_mv | 10.3892/ol.2018.9648 |
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Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer-adjacent tissues (P<0.05). In HCC tissues, FHIT expression was obviously positively correlated with p16 expression (Spearman's correlation coefficient, r=0.308; P=0.025). FHIT was related to HCC tumor-node-metastasis (TNM) staging, the differentiation degree in Edmondson-Steiner grading, lymph node metastasis and portal vein thrombosis (P<0.05 in all comparisons), whereas, p16 was associated with tumor size and the differentiation degree in Edmondson-Steiner grading (P<0.05 in all comparisons). The expression of FHIT and p16 genes and proteins in HCC tissues were obviously lower than those in cancer-adjacent tissues (P<0.05 in all comparisons). FHIT and p16 genes, as tumor suppressor genes, inhibit the proliferation of HCC, and there is a positive correlation between them. The proteins of the FHIT and p16 can be used as new indicators for clinical detection, thus providing a new method for clinical diagnosis.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.9648</identifier><identifier>PMID: 30655841</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Biological activity ; Biotechnology ; Care and treatment ; Cyclin-dependent kinases ; Development and progression ; Gene expression ; Genes ; Genetic aspects ; Health aspects ; Hepatocellular carcinoma ; Liver cancer ; Medical imaging ; Metastasis ; Methods ; Oncology ; Patient outcomes ; Patients ; Protein expression ; Proteins ; Therapeutic embolization ; Tumor suppressor genes</subject><ispartof>Oncology letters, 2019-01, Vol.17 (1), p.871-876</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Xu et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c467t-7eeeba81ad2a5bbf994fe4e51c328b44803cc2b3888a02bd6ede0ddcd0bae5f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313009/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313009/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30655841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Qi, Xiaogai</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Sun, Jize</creatorcontrib><title>Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer-adjacent tissues (P<0.05). In HCC tissues, FHIT expression was obviously positively correlated with p16 expression (Spearman's correlation coefficient, r=0.308; P=0.025). FHIT was related to HCC tumor-node-metastasis (TNM) staging, the differentiation degree in Edmondson-Steiner grading, lymph node metastasis and portal vein thrombosis (P<0.05 in all comparisons), whereas, p16 was associated with tumor size and the differentiation degree in Edmondson-Steiner grading (P<0.05 in all comparisons). The expression of FHIT and p16 genes and proteins in HCC tissues were obviously lower than those in cancer-adjacent tissues (P<0.05 in all comparisons). FHIT and p16 genes, as tumor suppressor genes, inhibit the proliferation of HCC, and there is a positive correlation between them. The proteins of the FHIT and p16 can be used as new indicators for clinical detection, thus providing a new method for clinical diagnosis.</description><subject>Biological activity</subject><subject>Biotechnology</subject><subject>Care and treatment</subject><subject>Cyclin-dependent kinases</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hepatocellular carcinoma</subject><subject>Liver cancer</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Oncology</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Therapeutic embolization</subject><subject>Tumor suppressor genes</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkktr3TAQhU1paUKaXddFUChd5N7qYcvyphBCXhDoJl0LSR7FCrLkSnZI_n1lkt7mlkoLidE3Z9CZqaqPBG-Z6Oi36LcUE7HteC3eVIek7eiGYEHf7u5tfVAd53yPy2o4EYK_rw4Y5k0janJY2XNrwcwoWuTCDOkBwuxiUB7BqKOP8wBJTU8oBnRxdX2LVOjRRDiCxylBzgUteWiASc3RgPeLVwkZlYwLcVSohF1RzB-qd1b5DMcv51H18-L89uxqc_Pj8vrs9GZjat7OmxYAtBJE9VQ1Wtuuqy3U0BDDqNB1LTAzhmomhFCY6p5DD7jvTY-1gsY27Kj6_qw7LXqE3pTaSXk5JTeq9CSjcnL_JbhB3sUHyRlhGHdF4OuLQIq_FsizHF1eP6YCxCVLWmxlLRakLejnf9D7uKRi3Upx2hbrKf9L3SkP0gUbS12zisrThneliV27am3_Q5Xdw-hMDGBdie8lfHmVMIDy85CjX9bm5X3w5Bk0KeacwO7MIFiuMySjl-sMyXWGCv7ptYE7-M_EsN8P48J0</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Xu, Wei</creator><creator>Qi, Xiaogai</creator><creator>Wang, Xia</creator><creator>Sun, Jize</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients</title><author>Xu, Wei ; Qi, Xiaogai ; Wang, Xia ; Sun, Jize</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-7eeeba81ad2a5bbf994fe4e51c328b44803cc2b3888a02bd6ede0ddcd0bae5f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biological activity</topic><topic>Biotechnology</topic><topic>Care and treatment</topic><topic>Cyclin-dependent kinases</topic><topic>Development and progression</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hepatocellular carcinoma</topic><topic>Liver cancer</topic><topic>Medical imaging</topic><topic>Metastasis</topic><topic>Methods</topic><topic>Oncology</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Therapeutic embolization</topic><topic>Tumor suppressor genes</topic><toplevel>online_resources</toplevel><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Qi, Xiaogai</creatorcontrib><creatorcontrib>Wang, Xia</creatorcontrib><creatorcontrib>Sun, Jize</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Wei</au><au>Qi, Xiaogai</au><au>Wang, Xia</au><au>Sun, Jize</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>17</volume><issue>1</issue><spage>871</spage><epage>876</epage><pages>871-876</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer-adjacent tissues (P<0.05). In HCC tissues, FHIT expression was obviously positively correlated with p16 expression (Spearman's correlation coefficient, r=0.308; P=0.025). FHIT was related to HCC tumor-node-metastasis (TNM) staging, the differentiation degree in Edmondson-Steiner grading, lymph node metastasis and portal vein thrombosis (P<0.05 in all comparisons), whereas, p16 was associated with tumor size and the differentiation degree in Edmondson-Steiner grading (P<0.05 in all comparisons). The expression of FHIT and p16 genes and proteins in HCC tissues were obviously lower than those in cancer-adjacent tissues (P<0.05 in all comparisons). FHIT and p16 genes, as tumor suppressor genes, inhibit the proliferation of HCC, and there is a positive correlation between them. The proteins of the FHIT and p16 can be used as new indicators for clinical detection, thus providing a new method for clinical diagnosis.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30655841</pmid><doi>10.3892/ol.2018.9648</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological activity Biotechnology Care and treatment Cyclin-dependent kinases Development and progression Gene expression Genes Genetic aspects Health aspects Hepatocellular carcinoma Liver cancer Medical imaging Metastasis Methods Oncology Patient outcomes Patients Protein expression Proteins Therapeutic embolization Tumor suppressor genes |
| title | Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients |
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