Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients

Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from...

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Veröffentlicht in:	Oncology letters 2019-01, Vol.17 (1), p.871-876
Hauptverfasser:	Xu, Wei, Qi, Xiaogai, Wang, Xia, Sun, Jize
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Biotechnology Care and treatment Cyclin-dependent kinases Development and progression Gene expression Genes Genetic aspects Health aspects Hepatocellular carcinoma Liver cancer Medical imaging Metastasis Methods Oncology Patient outcomes Patients Protein expression Proteins Therapeutic embolization Tumor suppressor genes
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Zusammenfassung:	Effects of interventional embolotherapy on the expression of fragile histidine triad (FHIT) and p16 in hepatocellular carcinoma (HCC) patients were investigated. Patients with primary HCC who were definitely diagnosed and treated in the Department of Gastroenterology in Qingdao Central Hospital from March 2014 to March 2016 were selected, and they underwent interventional embolotherapy. HCC and cancer-adjacent tissues of the patients were harvested for immunohistochemical staining. The correlation between the expression levels of FHIT and p16 was analyzed at the gene and protein level. Clinical data were collected, and whether they were correlated with the expression of FHIT and p16 was investigated. The expression levels of FHIT and p16 in primary HCC tissues were remarkably lower than that in cancer-adjacent tissues (P
ISSN:	1792-1074 1792-1082
DOI:	10.3892/ol.2018.9648