Stories of the future: manipulating RNA and Intra/Interkingdom communication

The vesicles make selective sorting of cargo, but all major RNA classes can be present and delivered to bacterial and/or eukaryotic cells. [...]RNA carried by these EVs can be considered as a universal mediator of communication (Tsatsaronis et al., ). If we consider that the intestine is colonized by approximately 100 trillion microorganisms comprising hundreds of different species, it is obvious that the intestinal EVs are a huge reservoir of microbial and parasitic antigens. [...]the role of EVs is an exciting frontier with important implications in the dynamics of host–pathogen interactions and vaccine applications. [...]our understanding of intra and interkingdom communication is still in its infancy but brings great promises. [...]my Crystal Ball is that RNA and Intra/Interkingdom communication will drive the most exciting progress in microbiology over the next few years.