Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation

Objectives Chlorogenic acid (CGA) is one of the most widely consumed polyphenols in diets and is recognized to be a natural hepatoprotective agent. Here, we evaluated the protective effect and the potential mechanism of CGA against ɑ‐naphthylisothiocyanate (ANIT)‐induced cholestasis and liver injury...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2016-09, Vol.68 (9), p.1203-1213
Hauptverfasser: Tan, Zhen, Luo, Min, Yang, Julin, Cheng, Yuqing, Huang, Jing, Lu, Caide, Song, Danjun, Ye, Meiling, Dai, Manyun, Gonzalez, Frank J., Liu, Aiming, Guo, Bin
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Sprache:eng
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Zusammenfassung:Objectives Chlorogenic acid (CGA) is one of the most widely consumed polyphenols in diets and is recognized to be a natural hepatoprotective agent. Here, we evaluated the protective effect and the potential mechanism of CGA against ɑ‐naphthylisothiocyanate (ANIT)‐induced cholestasis and liver injury. Methods Twenty‐five male 129/Sv mice were administered with CGA, and ANIT challenge was performed at 75 mg/kg on the 4th day. Blood was collected and subjected to biochemical analysis; the liver tissues were examined using histopathological analysis and signalling pathways. Key findings Chlorogenic acid almost totally attenuated the ANIT‐induced liver damage and cholestasis, compared with the ANIT group. Dose of 50 mg/kg of CGA significantly prevented ANIT‐induced changes in serum levels of alanine aminotransferase, alkaline phosphatases, total bile acid, direct bilirubin, indirect bilirubin (5.3‐, 6.3‐, 18.8‐, 158‐, 41.4‐fold, P
ISSN:0022-3573
2042-7158
DOI:10.1111/jphp.12592