Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. A literature search was condu...

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Veröffentlicht in:Bioscience reports 2018-12, Vol.38 (6)
Hauptverfasser: Yang, Yun, Liu, Rongxun, Ren, Feng, Guo, Rui, Zhang, Pengfei
Format: Artikel
Sprache:eng
Schlagworte:
Disease Progression
Humans
Leukocyte Count
Lymphocytes - pathology
Mouth Neoplasms - diagnosis
Mouth Neoplasms - pathology
Neoplasm Staging
Neutrophils - pathology
Prognosis
Survival Analysis
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Zusammenfassung:Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS ( =10, HR = 1.73, 95% confidence interval [CI] = 1.44-2.07,
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20181550