Association of Angiogenic and Inflammatory Markers with Power Doppler Ultrasound Vascularity Grade and DAS28-CRP in Early Rheumatoid Arthritis: A Comparative Analysis

Objective. Upregulation of various proinflammatory and angiogenic mediators orchestrates the typical pathological synovial alterations in rheumatoid arthritis (RA). DAS28-CRP is commonly used for assessment of RA disease activity and power Doppler ultrasonography (PDUS) is an important modality for...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-7
Hauptverfasser:	Sinhamahapatra, Pradyot, Guin, Aharna, Chatterjee, Sudipta, Mondal, Sumantro, Misra, Sanchaita, Ghosh, Alakendu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Angiopoietin Antirheumatic Agents - administration & dosage Arthritis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Biomarkers Biomarkers - metabolism Clinical Study Comparative analysis Cross-Sectional Studies Cytokines Cytokines - metabolism Diagnosis Disease control Doppler effect Evaluation Female Gene expression Grading Growth factors Health risk assessment Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin 6 Joint diseases Laboratories Male Markers Medical research Medicine, Experimental Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Pathogenesis Patients Quality Rheumatic diseases Rheumatoid arthritis Rheumatoid factor Rheumatology Serum levels Subgroups Synovial Membrane - drug effects Synovial Membrane - metabolism Synovitis - drug therapy Synovitis - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Ultrasonic imaging Ultrasonography, Doppler - methods Ultrasound Ultrasound imaging Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Wrist
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Zusammenfassung:	Objective. Upregulation of various proinflammatory and angiogenic mediators orchestrates the typical pathological synovial alterations in rheumatoid arthritis (RA). DAS28-CRP is commonly used for assessment of RA disease activity and power Doppler ultrasonography (PDUS) is an important modality for assessing synovial vascularity. This study was intended to look for the association of various inflammatory and angiogenic mediators, with respect to different PDUS vascularity grades and disease activity status, in early RA patients. Methods. 50 early RA patients (
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2018/6906374