Bone Marrow versus Peripheral Blood from Unrelated Donors for Children and Adolescents with Acute Leukemia

•There was higher overall mortality after peripheral blood transplant than with bone marrow transplant.•Lower relapse occurred after peripheral blood transplant than with bone marrow transplant.•No survival advantage was found despite lower relapse after peripheral blood transplant. Graft-versus-host disease (GVHD) rates are higher after unrelated donor transplantation; thus, we examined whether there would be differences in transplant outcomes by graft type in children and adolescents with acute leukemia. The primary endpoint was overall survival. We studied 872 patients