PSXII-18 Autophagy may contribute to variation in residual feed intake in Hereford cattle

Abstract Residual feed intake (RFI) is heritable and variable among cattle. Understanding gene pathways and networks that regulate variation in the trait will aid in the selection of efficient animals. A total of 824 Hereford steers (RFI: -3.65 to 3.13 kg/d) from nine contemporary groups were genoty...

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Veröffentlicht in:Journal of animal science 2018-12, Vol.96 (suppl_3), p.428-428
Hauptverfasser: Michal, J, Neibergs, H, Mutch, J, Kiser, J, Taylor, J, Consortium, U, Johnson, K
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Sprache:eng
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Zusammenfassung:Abstract Residual feed intake (RFI) is heritable and variable among cattle. Understanding gene pathways and networks that regulate variation in the trait will aid in the selection of efficient animals. A total of 824 Hereford steers (RFI: -3.65 to 3.13 kg/d) from nine contemporary groups were genotyped with either the Illumina BovineHD or BovineSNP50 BeadChip assays. A genome-wide association analysis was used to identify significant SNP (P3.0) and 55 LEG, was identified by the GSEA-SNP. Endopeptidases cleave peptide bonds and may affect RFI through their important enzymatic roles in protein digestion. The autophagy related 7 (ATG7) gene was the most significant (P=1.9x10-10) master regulator associated with RFI. Significant (P
ISSN:0021-8812
1525-3163
DOI:10.1093/jas/sky404.937