Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer
Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was det...
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| Veröffentlicht in: | Oncology reports 2019-01, Vol.41 (1), p.15-26 |
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| creator | Zhou, Huaping Chen, Allen Shen, Jianfei Zhang, Xiaoxue Hou, Min Li, Jin Chen, Jingyi Zou, Huan Zhang, Yingfei Deng, Qianren She, Kelin Shi, Xiaoshun He, Jianxing |
| description | Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P |
| doi_str_mv | 10.3892/or.2018.6839 |
| format | Article |
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This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P<0.001). Its expression was correlated with the tumor size (P=0.027). Kaplan-Meier analysis revealed that patients with lower LOC285194 expression had worse disease-free survival and overall survival rates (P<0.05). RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. Bioinformatics analyses suggested that depletion of LOC285149 could affect its antitumor function through the KRAS/BRAF/SMEK pathway. Our findings indicated that LOC285194 was a novel non-coding prognostic indicator and contributed to tumor suppression by targeting p53 in NSCLC, suggesting that it may be a non-coding target for NSCLC gene therapy.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.2018.6839</identifier><identifier>PMID: 30542733</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Biotechnology ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - pathology ; Care and treatment ; Cell growth ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation - genetics ; Development and progression ; Disease-Free Survival ; Experiments ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Gene therapy ; Genes, Tumor Suppressor ; Genetic aspects ; Health aspects ; Histology ; Humans ; Innovations ; Kaplan-Meier Estimate ; Lung - pathology ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lymphatic system ; Male ; Medical prognosis ; Medical research ; Metastasis ; Middle Aged ; Mutation ; Non-small cell lung cancer ; Plasmids ; Prognosis ; RNA ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Survival Rate ; Tumor suppressor genes ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Oncology reports, 2019-01, Vol.41 (1), p.15-26</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Zhou et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-516ac7d557958fdfd4d8952db8f3d342d33a3fab81413401608fb74eb117ebd93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30542733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Huaping</creatorcontrib><creatorcontrib>Chen, Allen</creatorcontrib><creatorcontrib>Shen, Jianfei</creatorcontrib><creatorcontrib>Zhang, Xiaoxue</creatorcontrib><creatorcontrib>Hou, Min</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Chen, Jingyi</creatorcontrib><creatorcontrib>Zou, Huan</creatorcontrib><creatorcontrib>Zhang, Yingfei</creatorcontrib><creatorcontrib>Deng, Qianren</creatorcontrib><creatorcontrib>She, Kelin</creatorcontrib><creatorcontrib>Shi, Xiaoshun</creatorcontrib><creatorcontrib>He, Jianxing</creatorcontrib><title>Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P<0.001). Its expression was correlated with the tumor size (P=0.027). Kaplan-Meier analysis revealed that patients with lower LOC285194 expression had worse disease-free survival and overall survival rates (P<0.05). RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. Bioinformatics analyses suggested that depletion of LOC285149 could affect its antitumor function through the KRAS/BRAF/SMEK pathway. Our findings indicated that LOC285194 was a novel non-coding prognostic indicator and contributed to tumor suppression by targeting p53 in NSCLC, suggesting that it may be a non-coding target for NSCLC gene therapy.</description><subject>Biotechnology</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Care and treatment</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Development and progression</subject><subject>Disease-Free Survival</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Knockdown Techniques</subject><subject>Gene therapy</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Histology</subject><subject>Humans</subject><subject>Innovations</subject><subject>Kaplan-Meier Estimate</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Non-small cell lung cancer</subject><subject>Plasmids</subject><subject>Prognosis</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Survival Rate</subject><subject>Tumor suppressor genes</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkl1rFDEUhgex2Fq981oGBOmFs-Z7khthWaotLBZEwbuQycduykwyJjNC_72ZtrZdkYTkkDznDefkrao3EKwwF-hjTCsEIF8xjsWz6gS2AjaIYPi8xADBBmP687h6mfM1AKgFTLyojjGgBLUYn1T9NoZdHWJodDS-hN--ruvt1QZxCgWp3Rz05GPItSqznuYhpjrP45hsziXsbupJpZ2dltSR4tqHW7E8qL6vtS1LP5crrYK26VV15FSf7ev7_bT68fn8--ai2V59udyst42mEEwNhUzp1lDaCsqdcYYYLigyHXfYYIIMxgo71XFIICYAMsBd1xLbQdjazgh8Wn260x3nbrBG2zAl1csx-UGlGxmVl4c3we_lLv6WDLWcUF4Ezu4FUvw12zzJweelGhVsnLNEkFIBOOe4oO_-Qa_jnEIpr1CkFMAEg4_UTvVW-uBieVcvonJNGSMAcMwKtfoPVYaxg9cxWOfL-UHC-ycJe6v6aZ9jP99-2SH44Q7UKeacrHtoBgRysZGMSS42kouNCv72aQMf4L--wX8AGVS_vA</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Zhou, Huaping</creator><creator>Chen, Allen</creator><creator>Shen, Jianfei</creator><creator>Zhang, Xiaoxue</creator><creator>Hou, Min</creator><creator>Li, Jin</creator><creator>Chen, Jingyi</creator><creator>Zou, Huan</creator><creator>Zhang, Yingfei</creator><creator>Deng, Qianren</creator><creator>She, Kelin</creator><creator>Shi, Xiaoshun</creator><creator>He, Jianxing</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Care and treatment</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Development and progression</topic><topic>Disease-Free Survival</topic><topic>Experiments</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Knockdown Techniques</topic><topic>Gene therapy</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Histology</topic><topic>Humans</topic><topic>Innovations</topic><topic>Kaplan-Meier Estimate</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Non-small cell lung cancer</topic><topic>Plasmids</topic><topic>Prognosis</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Survival Rate</topic><topic>Tumor suppressor genes</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Huaping</creatorcontrib><creatorcontrib>Chen, Allen</creatorcontrib><creatorcontrib>Shen, Jianfei</creatorcontrib><creatorcontrib>Zhang, Xiaoxue</creatorcontrib><creatorcontrib>Hou, Min</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>Chen, Jingyi</creatorcontrib><creatorcontrib>Zou, Huan</creatorcontrib><creatorcontrib>Zhang, Yingfei</creatorcontrib><creatorcontrib>Deng, Qianren</creatorcontrib><creatorcontrib>She, Kelin</creatorcontrib><creatorcontrib>Shi, Xiaoshun</creatorcontrib><creatorcontrib>He, Jianxing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Huaping</au><au>Chen, Allen</au><au>Shen, Jianfei</au><au>Zhang, Xiaoxue</au><au>Hou, Min</au><au>Li, Jin</au><au>Chen, Jingyi</au><au>Zou, Huan</au><au>Zhang, Yingfei</au><au>Deng, Qianren</au><au>She, Kelin</au><au>Shi, Xiaoshun</au><au>He, Jianxing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>41</volume><issue>1</issue><spage>15</spage><epage>26</epage><pages>15-26</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P<0.001). Its expression was correlated with the tumor size (P=0.027). Kaplan-Meier analysis revealed that patients with lower LOC285194 expression had worse disease-free survival and overall survival rates (P<0.05). RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. Bioinformatics analyses suggested that depletion of LOC285149 could affect its antitumor function through the KRAS/BRAF/SMEK pathway. Our findings indicated that LOC285194 was a novel non-coding prognostic indicator and contributed to tumor suppression by targeting p53 in NSCLC, suggesting that it may be a non-coding target for NSCLC gene therapy.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30542733</pmid><doi>10.3892/or.2018.6839</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biotechnology Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Development and progression Disease-Free Survival Experiments Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene therapy Genes, Tumor Suppressor Genetic aspects Health aspects Histology Humans Innovations Kaplan-Meier Estimate Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphatic system Male Medical prognosis Medical research Metastasis Middle Aged Mutation Non-small cell lung cancer Plasmids Prognosis RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Survival Rate Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism |
| title | Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer |
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