Long non-coding RNA LOC285194 functions as a tumor suppressor by targeting p53 in non-small cell lung cancer

Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was det...

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Veröffentlicht in:	Oncology reports 2019-01, Vol.41 (1), p.15-26
Hauptverfasser:	Zhou, Huaping, Chen, Allen, Shen, Jianfei, Zhang, Xiaoxue, Hou, Min, Li, Jin, Chen, Jingyi, Zou, Huan, Zhang, Yingfei, Deng, Qianren, She, Kelin, Shi, Xiaoshun, He, Jianxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Development and progression Disease-Free Survival Experiments Female Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Gene therapy Genes, Tumor Suppressor Genetic aspects Health aspects Histology Humans Innovations Kaplan-Meier Estimate Lung - pathology Lung cancer Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphatic system Male Medical prognosis Medical research Metastasis Middle Aged Mutation Non-small cell lung cancer Plasmids Prognosis RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Survival Rate Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	Recently, LOC285194 has shown a potential tumor-suppressor function in several types of human cancers, but its function in non-small cell lung cancer (NSCLC) remains unknown. This study intended to investigate the biological role of LOC285194 and its clinical significance in NSCLC. LOC285194 was detected by qRT-PCR, and its correlation with clinicopathological features of NSCLC was analyzed. The expression of LOC285194 was knocked down or ectopically expressed in lung cancer cells (A549 and H1299) and tumor cell growth, migration and invasion in vitro were investigated. In addition, the interaction of LOC285194 and target proteins was assessed by RNA pulldown and RNA immunoprecipitation in vitro. The results revealed that the expression of LOC285194 was significantly lower in tumor tissues when compared with the corresponding non-tumor tissues (P
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2018.6839