Decapping enzymes STOP “cancer” ribosomes in their tracks

Decapping enzymes STOP “cancer” ribosomes in their tracks

The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al ( 2018 ) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome biogenesis. PNRC1 relocalizes the Dcp1/Dcp2 mRNA decap...

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Veröffentlicht in:The EMBO journal 2018-12, Vol.37 (23), p.n/a
Hauptverfasser: Mugridge, Jeffrey S, Gross, John D
Format: Artikel
Sprache:eng
Schlagworte:
Biosynthesis
Cancer
Cell cycle
EMBO03
EMBO36
Endoribonucleases
Humans
mRNA
Neoplasms
News & Views
Nucleoli
Ribonucleic acid
Ribosomes
RNA
RNA processing
RNA, Ribosomal
rRNA
Tumor suppressor genes
Views
Yeast
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Beschreibung
Zusammenfassung:The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al ( 2018 ) shows that mRNA decapping coactivator PNRC1 acts as a tumor suppressor by regulating ribosome biogenesis. PNRC1 relocalizes the Dcp1/Dcp2 mRNA decapping complex to the nucleolus and promotes decapping of specific snoRNAs to disrupt the processing of ribosomal RNA. By slowing rRNA processing, and thus ribosome biogenesis, PNRC1 acts as a gatekeeper that restrains oncogenic potential. Graphical Abstract The mRNA decapping coactivator PNRC1 disrupts rRNA processing and ribosome biogenesis, thereby acting as a tumour suppressor.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2018100801