FBXW7 modulates malignant potential and cisplatin‐induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1

FBXW7 modulates malignant potential and cisplatin‐induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1

The ubiquitin ligase F‐box and WD repeat domain‐containing 7 (FBXW7) is responsible for degrading diverse oncoproteins and is considered a tumor suppressor in many human cancers. Inhibiting FBXW7 enhances the malignant potential of several cancers. In this study, we aimed to investigate the role of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer science 2018-12, Vol.109 (12), p.3883-3895
Hauptverfasser: Mori, Akiko, Masuda, Kunihiro, Ohtsuka, Hideo, Shijo, Masahiro, Ariake, Kyohei, Fukase, Koji, Sakata, Naoaki, Mizuma, Masamichi, Morikawa, Takanori, Hayashi, Hiroki, Nakagawa, Kei, Motoi, Fuyuhiko, Naitoh, Takeshi, Fujishima, Fumiyoshi, Unno, Michiaki
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Bile Duct Neoplasms - metabolism
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
cholangiocarcinoma
Cholangiocarcinoma - metabolism
cisplatin
Cisplatin - pharmacology
Disease Progression
Down-Regulation
F-Box-WD Repeat-Containing Protein 7 - metabolism
FBXW7 protein
Gene Expression Regulation, Neoplastic
Humans
Middle Aged
myeloid cell leukemia sequence 1 protein
Myeloid Cell Leukemia Sequence 1 Protein - metabolism
NOTCH1 protein
Original
Prognosis
Receptor, Notch1 - metabolism
Survival Analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The ubiquitin ligase F‐box and WD repeat domain‐containing 7 (FBXW7) is responsible for degrading diverse oncoproteins and is considered a tumor suppressor in many human cancers. Inhibiting FBXW7 enhances the malignant potential of several cancers. In this study, we aimed to investigate the role of FBXW7 in cholangiocarcinoma. We found that FBXW7 expression was associated with clinicopathological outcomes in cholangiocarcinoma patients. Both disease‐free and overall survival were significantly worse in the low‐FBXW7 group than in the high‐FBXW7 group (P = .001 and P 
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.13829