Three new myrsinol diterpenes from Euphorbia prolifera and their neuroprotective activities

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2012-08, Vol.17 (8), p.9520-9528
Hauptverfasser:	Xu, Jing, Jin, Daqing, Guo, Ping, Xie, Chunfeng, Fang, Lingzhi, Guo, Yuanqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Cell death Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Euphorbia - chemistry Humans Medical research Natural products Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Pharmacy Plant Roots - chemistry
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Zusammenfassung:	Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+ -induced neuronal cell death in SH-SY5Y cells.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules17089520