Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives

Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives

Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2 N -substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h wer...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2009-09, Vol.14 (9), p.3494-3508
Hauptverfasser: Pau, Amedeo, Murineddu, Gabriele, Asproni, Battistina, Murruzzu, Caterina, Grella, Giuseppe E., Pinna, Gérard A., Curzu, Maria M., Marchesi, Irene, Bagella, Luigi
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Sprache:eng
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Zusammenfassung:Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of 2 N -substituted-hexahydrothieno-cycloheptapyridazinone derivatives were synthesized and their biological activity evaluated. Among the synthesized compounds, derivatives 7d and 7h were found to possess cytotoxic activity against non-small cell lung cancer and central nervous system cancer cell lines, respectively.
ISSN:1420-3049
DOI:10.3390/molecules14093494