Postprandial Hyperlipemia is an Indication for Additional Risk in Sitosterolemia

[See article vol. 25 : 1188-1195] Postprandial hyperlipidemia is a condition in which triglyceride (TG)-rich lipoproteins, including exogenous chylomicron and endogenous VLDL and their remnants, accumulate after meals. Although approximately four decades ago, Zilversmit proposed, for the first time, that atherogenesis is a postprandial phenomenon, little attention has been paid to this notion for a while afterward. However, recent epidemiological studies have demonstrated that non-fasting, but not fasting, TG levels are associated with increased coronary heart disease (CHD). In addition, it is noteworthy that most of the day is considered as a non-fasting state. After meals, exogenous chylomicron are introduced into the circulation and cleared through mechanisms which are, to some degree, in common to those for clearing endogenous VLDL.