Anal High-Grade Squamous Intraepithelial Lesions in Human Immunodeficiency Virus-Infected Men: A Study of 100 Cases With Emphasis on Cytohistologic Correlation

Anal High-Grade Squamous Intraepithelial Lesions in Human Immunodeficiency Virus-Infected Men: A Study of 100 Cases With Emphasis on Cytohistologic Correlation

Anorectal cytology (ARC) is a widely used screening tool for anal cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Its diagnostic accuracy needs to be improved, especially for high-grade squamous intraepithelial lesions (HSILs). Using 100 HIV+ MSM with biopsy-pr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of clinical pathology 2017-03, Vol.147 (3), p.315-321
Hauptverfasser: Liu, Yuxin, Wang, Xiaofei, Kalir, Tamara, Chhieng, David, Sigel, Keith, Gaisa, Michael M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Anal cancer
Anorectal
Anus
Anus Neoplasms - diagnosis
Anus Neoplasms - pathology
Anus Neoplasms - virology
Biopsy
Cancer
Carcinoma in Situ - diagnosis
Carcinoma in Situ - pathology
Carcinoma in Situ - virology
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - virology
Cellular biology
Colorectal cancer
Cytodiagnosis - methods
Cytology
Early Detection of Cancer - methods
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Male
Middle Aged
Neoplasm Grading
Original
Squamous cells
Testing
Young Adult
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Anorectal cytology (ARC) is a widely used screening tool for anal cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Its diagnostic accuracy needs to be improved, especially for high-grade squamous intraepithelial lesions (HSILs). Using 100 HIV+ MSM with biopsy-proven anal HSILs, we correlated histologic/cytologic findings. Upon review, HSIL cells were present in 58 cytology samples and absent in 42. Positive samples were higher in cellularity and contained transformation zones ( P  
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqw229