LOW LUNG FUNCTION IS A PREDICTOR OF MORTALITY ALSO ADJUSTED FOR SARCOPENIA

Low lung function has been related to functional aging, chronic bronchitis and cardiovascular disease. However, low lung function has also been associated to muscle function and body size. The purpose of this study was to examine if low lung function is an independent predictor of 10 year mortality (379 died). We examined lung function with spirometry in 1010 men, age 69–80 years in the Gothenburg part of the Swedish MrOS-study. Both forced expiratory volume 1.0(FEV1.0) and vital capacity (VC) decreased with age, and the age corrected HR for 10 year mortality per SD decrease in FEV1.0 was 1.39 (CI 1.25–1.54) and for VC 1.38 (CI 1.24–1.53). Bone mineral density (BMD) and body composition (including appendicular lean mass) was measured with Hologic 4500 A. Hand grip strength was measured with a Jamar dynamometer. FEV1.0 associated with hand grip strength (r= 0.36, p