EUS-guided fine needle biopsy of pancreatic masses can yield true histology

Correspondence to Dr Shyam Varadarajulu, Center for Interventional Endoscopy, Florida Hospital, Orlando, Florida, FL 32803, USA; svaradarajulu@yahoo.com Message As cytological aspirates from endoscopic-ultrasound-guided fine needle aspiration (EUS-FNA) has limited diagnostic sensitivity and are suboptimal for molecular profiling and morphological characterisation of certain neoplasms, a fine needle biopsy (FNB) with three-pronged (Franseen geometry) cutting edge has been developed to procure histology. [...]when a rare diagnosis is suspected or if the need for ancillary testing is anticipated, then EUS-guided tissue acquisition using an FNB needle can be specifically requested. [...]although molecular biomarkers may be prognostically useful, their application outside of clinical trials is limited. [...]not all pancreatic masses require FNB sampling. [...]the Franseen biopsy needle enables acquisition of true histological core