Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol

Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol

An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and -aminobenzaldehydes a cascade dearomatization/rearomatization/dearomatization sequenc...

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Veröffentlicht in:Chemical science (Cambridge) 2018-11, Vol.9 (43), p.8253-8259
Hauptverfasser: Li, Shuai-Shuai, Lv, Xintong, Ren, Didi, Shao, Chang-Lun, Liu, Qing, Xiao, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Chemical industry
Chemistry
Crystallography
Hydrides
Hydrogen bonding
Hydrogen storage
Phenols
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Zusammenfassung:An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and -aminobenzaldehydes a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions.
ISSN:2041-6520
2041-6539
DOI:10.1039/c8sc03339k