Splenic mass in a case of CALR‐mutated essential thrombocythemia

Splenic mass in a case of CALR‐mutated essential thrombocythemia

Key Clinical Message We report here an intrasplenic large mass in an elderly case of essential thrombocythemia (ET)‐myelofibrosis. Laparoscopic splenectomy revealed extramedullary hematopoiesis (EMH) and a type 1 CALR gene mutation (CALR‐c.1092_1143del52) in the splenic mass. It remains to be determ...

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Veröffentlicht in:Clinical case reports 2018-11, Vol.6 (11), p.2291-2292
Hauptverfasser: Imashuku, Shinsaku, Kotani, Shinichi, Hinami, Junsuke, Nishimura, Keisuke
Format: Artikel
Sprache:eng
Schlagworte:
calreticulin
Case reports
Clinical Image
Clinical Images
essential thrombocythemia
extramedullary hematopoiesis
myelofibrosis
splenic mass
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Zusammenfassung:Key Clinical Message We report here an intrasplenic large mass in an elderly case of essential thrombocythemia (ET)‐myelofibrosis. Laparoscopic splenectomy revealed extramedullary hematopoiesis (EMH) and a type 1 CALR gene mutation (CALR‐c.1092_1143del52) in the splenic mass. It remains to be determined if CALR‐mutated ET has an increased tendency to develop mass‐forming EMH. We report here an intrasplenic large mass in an elderly case of essential thrombocythemia (ET)‐myelofibrosis. Laparoscopic splenectomy revealed extramedullary hematopoiesis (EMH) and a type 1 CALR gene mutation (CALR‐c.1092_1143del52) in the splenic mass. It remains to be determined if CALR‐mutated ET has an increased tendency to develop mass‐forming EMH.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.1857