Higher follicular fluid glycodelin levels are negatively correlated with embryonic development in assisted reproduction

To investigate the possible effect of follicular fluid glycodelin levels on the quality of developing oocytes and subsequent embryo development. Follicular fluid glycodelin levels of 145 patients undergoing assisted reproductive treatment were analyzed and the correlation between glycodelin levels and ART outcomes were evaluated. We found that glycodelin levels were negatively correlated with the number of high quality embryos on day 3 (r=-0.20, =0.05). Additionally, higher glycodelin levels were correlated with higher FSH levels (r=0.18, p=0.04). However, glycodelin levels were not predictive for implantation ( =0.67) or ongoing pregnancy rates ( =0.99). Glycodelin in the follicular environment might be one of the factors that influence the competence of growing oocytes and affect the quality of subsequent in vitro embryo development.