MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1

Primary colon adenocarcinoma is responsible for high rates of mortality worldwide. The late diagnosis and lack of reliable biomarkers and therapeutic targets forms a bottleneck in the treatment of colon cancer. In the present study, the therapeutic potential of an important microRNA (miR), namely mi...

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Veröffentlicht in:	International journal of molecular medicine 2018-12, Vol.42 (6), p.3171-3180
Hauptverfasser:	Yang, Yong, Li, Xiao-Jia, Li, Peng, Guo, Xiu-Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Animals Apoptosis Apoptosis - genetics Binding sites Biomarkers Cancer Cell cycle Cell Line, Tumor Cell Movement - genetics Cell Proliferation Colonic Neoplasms - genetics Ectopic Gene Expression Gene Expression Regulation, Neoplastic Heterografts Humans Kinases Male Metastasis Mice MicroRNAs MicroRNAs - genetics Microscopy Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Polymerase chain reaction Proteins RNA Interference Tumors
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Zusammenfassung:	Primary colon adenocarcinoma is responsible for high rates of mortality worldwide. The late diagnosis and lack of reliable biomarkers and therapeutic targets forms a bottleneck in the treatment of colon cancer. In the present study, the therapeutic potential of an important microRNA (miR), namely miR‑145, was investigated in primary colon adenocarcinoma cells. The results revealed that the expression of miR‑145 was significantly (P
ISSN:	1107-3756 1791-244X
DOI:	10.3892/ijmm.2018.3904