In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species

In Vitro Activity of PBTZ169 against Multiple Mycobacterium Species

In this study, we demonstrate that PBTZ169 exhibits significant differences in activity against multiple species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for susceptibility to PBTZ169 in mycobacteria. In additio...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2018-11, Vol.62 (11)
Hauptverfasser: Shi, Jin, Lu, Jie, Wen, Shu'an, Zong, Zhaojing, Huo, Fengmin, Luo, Jingjing, Liang, Qian, Li, Yunxu, Huang, Hairong, Pang, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Antitubercular Agents
Mechanisms of Resistance
Mycobacterium
Piperazines
Thiazines
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Zusammenfassung:In this study, we demonstrate that PBTZ169 exhibits significant differences in activity against multiple species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for susceptibility to PBTZ169 in mycobacteria. In addition, the amino acid substitution at codon 154 in DprE1 may be associated with acquired resistance to PBTZ169 in the mutants.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01314-18